https://thegenerativebrain.org/updates/Dated developments in prion disease research, trials, tests and rules.en https://thegenerativebrain.org/atlas/funding-programs/cjd-foundation-research-grants//atlas/funding-programs/cjd-foundation-research-grants/#2026-10-30-Full grant and fellowship applications dFri, 30 Oct 2026 00:00:00 GMTFull grant and fellowship applications due. https://thegenerativebrain.org/atlas/organizations/cjd-foundation//atlas/organizations/cjd-foundation/#2026-10-30-Full applications and fellowship applicaFri, 30 Oct 2026 00:00:00 GMTFull applications and fellowship applications due. https://thegenerativebrain.org/atlas/trials/studies/clime-cjd-fujian//atlas/trials/studies/clime-cjd-fujian/#2026-10-30-Latest record version seen by this workeFri, 30 Oct 2026 00:00:00 GMTLatest record version seen by this worker. https://thegenerativebrain.org/atlas/regulations/us-fda-surrogate-endpoint-type-c-meeting//atlas/regulations/us-fda-surrogate-endpoint-type-c-meeting/#2026-10-29-Surrogate endpoint table page current asThu, 29 Oct 2026 00:00:00 GMTSurrogate endpoint table page current as of this date. https://thegenerativebrain.org/atlas/therapies/aln6457//atlas/therapies/aln6457/#2026-10-23-Estimated start of the Phase 1/2 trial.Fri, 23 Oct 2026 00:00:00 GMTEstimated start of the Phase 1/2 trial. https://thegenerativebrain.org/atlas/organizations/alnylam//atlas/organizations/alnylam/#2026-10-23-Estimated trial start; the record read oFri, 23 Oct 2026 00:00:00 GMTEstimated trial start; the record read on 2026-10-31 still showed not yet recruiting. https://thegenerativebrain.org/atlas/organizations/regeneron//atlas/organizations/regeneron/#2026-10-23-Estimated start of the ALN-6457 trial.Fri, 23 Oct 2026 00:00:00 GMTEstimated start of the ALN-6457 trial. https://thegenerativebrain.org/atlas/trials/aln6457//atlas/trials/aln6457/#2026-10-23-Estimated start.Fri, 23 Oct 2026 00:00:00 GMTEstimated start. https://thegenerativebrain.org/atlas/organizations/fda-oopd//atlas/organizations/fda-oopd/#2026-10-20-Next receipt date for RFA-FD-25-020.Tue, 20 Oct 2026 00:00:00 GMTNext receipt date for RFA-FD-25-020. https://thegenerativebrain.org/atlas/funding-programs/anthropic-ai-for-science//atlas/funding-programs/anthropic-ai-for-science/#2026-10-20-Official rules last updated.Tue, 20 Oct 2026 00:00:00 GMTOfficial rules last updated. https://thegenerativebrain.org/atlas/funding-programs/fda-orphan-products-grants//atlas/funding-programs/fda-orphan-products-grants/#2026-10-20-Second application date under RFA-FD-25-Tue, 20 Oct 2026 00:00:00 GMTSecond application date under RFA-FD-25-020; passed as of 2026-11-01. https://thegenerativebrain.org/atlas/therapies/nsc500-polythiophene//atlas/therapies/nsc500-polythiophene/#2026-10-17-No registered trial found on ClinicalTriSat, 17 Oct 2026 00:00:00 GMTNo registered trial found on ClinicalTrials.gov; Union Register status unconfirmed. https://thegenerativebrain.org/atlas/trials/studies/irta-scjd-scrapie-origin//atlas/trials/studies/irta-scjd-scrapie-origin/#2026-10-17-Six Europe PMC searches and the IRTA newSat, 17 Oct 2026 00:00:00 GMTSix Europe PMC searches and the IRTA news feed find no publication, abstract or news item reporting an outcome of the bioassay. https://thegenerativebrain.org/atlas/therapies/adam8-gt//atlas/therapies/adam8-gt/#2026-10-16-Searches find no peer-reviewed paper, prFri, 16 Oct 2026 00:00:00 GMTSearches find no peer-reviewed paper, preprint or registry entry for this gene therapy. https://thegenerativebrain.org/atlas/tests/prnp-seq//atlas/tests/prnp-seq/#2026-10-16-Depth pass: NPDPSC, Florey, Fulgent, DNAFri, 16 Oct 2026 00:00:00 GMTDepth pass: NPDPSC, Florey, Fulgent, DNA Labs India, GeneReviews and UCL pages read. https://thegenerativebrain.org/atlas/tests/rtquic-e219k-substrate//atlas/tests/rtquic-e219k-substrate/#2026-10-16-Search for later use or citation of the Fri, 16 Oct 2026 00:00:00 GMTSearch for later use or citation of the substrate found no 2026 paper and no laboratory adoption record. https://thegenerativebrain.org/atlas/organizations/aiims-rishikesh//atlas/organizations/aiims-rishikesh/#2026-10-16-Department page lists Mritunjai Kumar asFri, 16 Oct 2026 00:00:00 GMTDepartment page lists Mritunjai Kumar as Associate Professor and Head. https://thegenerativebrain.org/atlas/organizations/blueprint-genetics//atlas/organizations/blueprint-genetics/#2026-10-16-Stand alone PRNP single gene test page rFri, 16 Oct 2026 00:00:00 GMTStand alone PRNP single gene test page returns not found. https://thegenerativebrain.org/atlas/organizations/cegat//atlas/organizations/cegat/#2026-10-16-Older dementia panel URL returns not fouFri, 16 Oct 2026 00:00:00 GMTOlder dementia panel URL returns not found; current panel sits under neurodegenerative diseases as NDD17. https://thegenerativebrain.org/atlas/organizations/dna-labs-india//atlas/organizations/dna-labs-india/#2026-10-16-Four PRNP NGS records confirmed in NCBI Fri, 16 Oct 2026 00:00:00 GMTFour PRNP NGS records confirmed in NCBI GTR; NABL directory unreachable. https://thegenerativebrain.org/atlas/organizations/fulgent//atlas/organizations/fulgent/#2026-10-16-Fulgent PRNP test pages return HTTP 403 Fri, 16 Oct 2026 00:00:00 GMTFulgent PRNP test pages return HTTP 403 to automated fetch; details rest on search excerpts. https://thegenerativebrain.org/atlas/tests/rtquic-csf//atlas/tests/rtquic-csf/#2026-10-15-Evidence read for this dossier.Thu, 15 Oct 2026 00:00:00 GMTEvidence read for this dossier. https://thegenerativebrain.org/atlas/organizations/cjdisa//atlas/organizations/cjdisa/#2026-10-15-CJDISA posts a community statement on PRThu, 15 Oct 2026 00:00:00 GMTCJDISA posts a community statement on PRiSM opening to pre-symptomatic participants. https://thegenerativebrain.org/atlas/organizations/dna-labs-india//atlas/organizations/dna-labs-india/#2026-10-15-Entity first recorded in the Atlas from Thu, 15 Oct 2026 00:00:00 GMTEntity first recorded in the Atlas from the PRNP vendor listing. https://thegenerativebrain.org/atlas/therapies/antibody-prn100//atlas/therapies/antibody-prn100/#2026-10-14-CJD Foundation drug development page lisWed, 14 Oct 2026 00:00:00 GMTCJD Foundation drug development page lists PRN100 as not currently enrolling. https://thegenerativebrain.org/atlas/therapies/prp-sirna//atlas/therapies/prp-sirna/#2026-10-14-PRiSM pre-symptomatic arm announced.Wed, 14 Oct 2026 00:00:00 GMTPRiSM pre-symptomatic arm announced. https://thegenerativebrain.org/atlas/trials/prism//atlas/trials/prism/#2026-10-14-Pre-symptomatic arm announced as openingWed, 14 Oct 2026 00:00:00 GMTPre-symptomatic arm announced as opening. https://thegenerativebrain.org/atlas/therapies/zfr//atlas/therapies/zfr/#2026-10-13-Sale reported closed.Tue, 13 Oct 2026 00:00:00 GMTSale reported closed. https://thegenerativebrain.org/atlas/organizations/eli-lilly//atlas/organizations/eli-lilly/#2026-10-13-Sangamo reports the Lilly sale has closeTue, 13 Oct 2026 00:00:00 GMTSangamo reports the Lilly sale has closed. https://thegenerativebrain.org/atlas/organizations/sangamo//atlas/organizations/sangamo/#2026-10-13-Lilly and PTC sales reported closed.Tue, 13 Oct 2026 00:00:00 GMTLilly and PTC sales reported closed. https://thegenerativebrain.org/atlas/therapies/anle138b-oligomer-modulator//atlas/therapies/anle138b-oligomer-modulator/#2026-10-09-TOPAS-MSA registry record last updated; Fri, 09 Oct 2026 00:00:00 GMTTOPAS-MSA registry record last updated; status active, not recruiting. https://thegenerativebrain.org/atlas/tests/blood-markers//atlas/tests/blood-markers/#2026-10-06-UCH-L1 biomarker paper published.Tue, 06 Oct 2026 00:00:00 GMTUCH-L1 biomarker paper published. https://thegenerativebrain.org/atlas/organizations/lcv-algete//atlas/organizations/lcv-algete/#2026-10-01-New designation order in force: Algete nThu, 01 Oct 2026 00:00:00 GMTNew designation order in force: Algete named for TSEs and for PRNP analysis in the sheep resistance programme; Real Decreto 148/2023 repealed. https://thegenerativebrain.org/atlas/organizations/unizar-prion-zaragoza//atlas/organizations/unizar-prion-zaragoza/#2026-10-01-New national reference laboratory order Thu, 01 Oct 2026 00:00:00 GMTNew national reference laboratory order in force; TSEs assigned to Algete, Zaragoza not named. https://thegenerativebrain.org/atlas/regulations/es-rd-21-2013//atlas/regulations/es-rd-21-2013/#2026-10-01-New article 14 in force; the designationThu, 01 Oct 2026 00:00:00 GMTNew article 14 in force; the designation order names Algete for PRNP analysis in the programme. https://thegenerativebrain.org/atlas/regulations/es-rd-3454-2000//atlas/regulations/es-rd-3454-2000/#2026-10-01-Amended articles 3.1, 3.2 and 6.3.c in fThu, 01 Oct 2026 00:00:00 GMTAmended articles 3.1, 3.2 and 6.3.c in force; national TSE reference laboratory now set by the designation order, which names Algete. https://thegenerativebrain.org/atlas/tests/pet-blot//atlas/tests/pet-blot/#2026-10-PET blot listed among Homburg prion and Thu, 01 Oct 2026 00:00:00 GMTPET blot listed among Homburg prion and aggregate diagnostics (page read 2026-10-17). https://thegenerativebrain.org/atlas/organizations/kdca-cjd-surveillance//atlas/organizations/kdca-cjd-surveillance/#2026-10-KDCA pre-procedure CJD infection-risk scThu, 01 Oct 2026 00:00:00 GMTKDCA pre-procedure CJD infection-risk screening guide dated 7 October (secondary, unopened). https://thegenerativebrain.org/atlas/organizations/uthealth-houston//atlas/organizations/uthealth-houston/#2026-10-eNeuro paper: TMEM106B loss does not altThu, 01 Oct 2026 00:00:00 GMTeNeuro paper: TMEM106B loss does not alter prion disease in mice. https://thegenerativebrain.org/atlas/papers/martheswaran-2020-corneal-cjd-risk//atlas/papers/martheswaran-2020-corneal-cjd-risk/#2026-10-Europe PMC lists 13 citing articles.Thu, 01 Oct 2026 00:00:00 GMTEurope PMC lists 13 citing articles. https://thegenerativebrain.org/atlas/funding-programs/dod-national-prion-research-program//atlas/funding-programs/dod-national-prion-research-program/#2026-10-CDMRP funding table, updated 21 October Thu, 01 Oct 2026 00:00:00 GMTCDMRP funding table, updated 21 October 2026, still shows National Prion only for FY02. https://thegenerativebrain.org/atlas/regulations/eu-plasma-process-vcjd-guideline-2004//atlas/regulations/eu-plasma-process-vcjd-guideline-2004/#2026-10-EMA page still shows the October 2004 teThu, 01 Oct 2026 00:00:00 GMTEMA page still shows the October 2004 text as the current effective version, last updated 21 October 2004. https://thegenerativebrain.org/atlas/organizations/cjd-care-india//atlas/organizations/cjd-care-india/#2026-10-Listed as a full member association in tThu, 01 Oct 2026 00:00:00 GMTListed as a full member association in the CJDISA directory. https://thegenerativebrain.org/atlas/organizations/cjd-support-nz//atlas/organizations/cjd-support-nz/#2026-10-Listed as a CJDISA member association inThu, 01 Oct 2026 00:00:00 GMTListed as a CJDISA member association in the alliance directory (page undated, retrieved this month). https://thegenerativebrain.org/atlas/organizations/selbsthilfegruppe-prionen-at//atlas/organizations/selbsthilfegruppe-prionen-at/#2026-10-Online relatives meeting on 16 October, Thu, 01 Oct 2026 00:00:00 GMTOnline relatives meeting on 16 October, with further dates in November and December. https://thegenerativebrain.org/atlas/funding-programs/cjd-foundation-research-grants//atlas/funding-programs/cjd-foundation-research-grants/#2026-09-30-Deadline for invitations to submit full Wed, 30 Sep 2026 00:00:00 GMTDeadline for invitations to submit full applications. https://thegenerativebrain.org/atlas/funding-programs/fda-rare-neurodegenerative-grants//atlas/funding-programs/fda-rare-neurodegenerative-grants/#2026-09-30-Final fiscal year end of the Act's 100 mWed, 30 Sep 2026 00:00:00 GMTFinal fiscal year end of the Act's 100 million USD annual authorization (FY2022 to FY2026). https://thegenerativebrain.org/atlas/organizations/cjd-foundation//atlas/organizations/cjd-foundation/#2026-09-30-Selected letter-of-intent applicants notWed, 30 Sep 2026 00:00:00 GMTSelected letter-of-intent applicants notified. https://thegenerativebrain.org/atlas/organizations/lcv-algete//atlas/organizations/lcv-algete/#2026-09-30-BOE publishes Real Decreto 682/2026, OrdWed, 30 Sep 2026 00:00:00 GMTBOE publishes Real Decreto 682/2026, Orden PJC/1015/2026 and Orden APA/1016/2026. https://thegenerativebrain.org/atlas/organizations/rki-prion-unit//atlas/organizations/rki-prion-unit/#2026-09-30-RKI unit page lists Group 3, Prions and Wed, 30 Sep 2026 00:00:00 GMTRKI unit page lists Group 3, Prions and Prionoids, under Achim Thomzig.