The Generative Brain

Tel Aviv Medical Center (Sourasky), Cognitive Neurology Unit

Tel Aviv Sourasky Medical Center, home of the Cognitive Neurology Unit that runs the natural history study of preclinical genetic CJD in the world's largest E200K at-risk population.

Key facts

  • Single site in Israel (Cognitive Neurology Unit, Tel Aviv Medical Center), recruiting; PI Noa Bregman; two groups: genetic CJD patients and first-degree healthy relatives (carriers and non-carriers of E200K); yearly in-depth visits for four years with clinical evaluation, blood and urine, gait, brain MRI, lumbar puncture and polysomnography; requires willingness to undergo genetic testing.
  • The protocol lists the Cognitive Neurology Unit of the Neurological Institute, a laboratory of biomarkers and genomics of neurodegeneration, the Wohl Institute for Advanced Imaging and clinical laboratories as participating units, with Tel Aviv University schools.
  • The registered study has one site there (Cognitive Neurology Unit), listed as recruiting, with Noa Bregman as principal investigator.
  • The 2025 JNNP paper from the center reports diffusion MRI changes in healthy E200K carriers with raised CSF tau and was funded by Ionis.
  • The protocol describes about 200,000 Libyan Jews in Israel, the largest at-risk population in the world, as the setting.

Timeline

  1. 2023Study protocol published.
  2. 2025JNNP paper on white matter in healthy E200K carriers.
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