Key facts
- Lead author of the second-generation RT-QuIC paper (mBio 2015) and of the 2020 six-laboratory ring trial; staff scientist on Caughey's team for 19 years and trained people at about 30 laboratories.
- First author of the 2014 NEJM nasal brushing RT-QuIC study (97 percent sensitivity and 100 percent specificity).
- By 2019 she had trained people at about 30 laboratories on RT-QuIC, according to a tribute to Byron Caughey.
- She is lead author with Groveman and Caughey of the 2025 chapter Tracking Prions by RT-QuIC: An Update.
- She is named among the colleagues in Caughey's lab in 2019 and a co-contributor of the CWD rectal mucosa RT-QuIC protocol.
- A named inventor on the NIH bank vole substrate technology listing (as Christina Groveman).
Timeline
- 2014NEJM nasal brushing paper.
- 2019Named in the RML team photo.
- 2025RT-QuIC update chapter online.
Institutions
Projects and trials
Research papers
Works with
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Last checked 16 October 2026
Sources for this page
- Remembering Dr. Byron Caughey (Bitterroot Star, 3 Mar 2026)
- Rapid and Sensitive RT-QuIC Detection of Human CJD Using CSF (mBio, Feb 2015)
- Ring trial of 2nd generation RT-QuIC diagnostic tests for sporadic CJD (Ann Clin Transl Neurol, Nov 2020)
- Orru et al.: a test for Creutzfeldt-Jakob disease using nasal brushings (NEJM 2014; abstract record)
- cureffi: Celebrating Byron Caughey, 1957-2026
- Orru CD, Groveman BR, Caughey B. Tracking Prions by RT-QuIC: An Update. Subcellular Biochemistry vol 112 (first online 1 October 2025)
- protocols.io: RT-QuIC assay for detection of chronic wasting disease in rectal mucosa of white-tailed deer (2024)
- NIH Office of Technology Transfer, TAB-4930: broadly reactive substrates and strain discrimination (published 26 August 2026)