Dorina Tiple

Key facts

• The ISS registry staff list revised in November 2024 names D Tiple as one of two consultant neurologists, alongside L Vaianella, under Anna Ladogana as head of the National Registry of CJD.
• A self reported physician profile gives a neurology specialisation from Carol Davila University of Medicine and Pharmacy, Bucharest (2010), a movement disorders fellowship at Sapienza University of Rome in 2005 to 2006, and work at the Sapienza movement disorders clinic from 2010, including consultation on CJD and other dementias.
• Her first author papers in 2008 and 2009 were movement disorder studies from the Sapienza Department of Neurological Sciences, including a 2009 JNNP study that found camptocormia in about 6.9 percent of 275 Parkinson disease outpatients.
• She was a co-author of the 2013 PLoS One study by Pocchiari and ISS colleagues that compared age at death across two generations of the southern Italian E200K cluster and reported younger age at death in the offspring generation (study level).
• She was a co-author of the 2017 JAMA Neurology study showing that RT-QuIC on olfactory mucosa combined with CSF gave very high sensitivity and specificity for prion disease in life, with an ISS Department of Cell Biology and Neurosciences affiliation.
• She was first author of a 2019 Acta Neuropathologica Communications clinicopathological report on the rare genetic CJD form linked to the PRNP R208H variant, written with Poleggi, Ladogana, Parchi and Pocchiari and funded by an ISS grant.
• On the January 2022 JAMA Network Open validation of revised international surveillance criteria for sporadic CJD her affiliation is the Registry of Creutzfeldt-Jakob Disease, ISS Department of Neuroscience; the revised criteria, which add MRI cortical ribboning and RT-QuIC, picked up more autopsy confirmed cases without loss of specificity.
• She was author 4 of 13 on the 2023 JNNP study of 1,250 patients with suspected CJD seen at two Italian reference centres, which found the amended criteria more sensitive at first evaluation and CSF RT-QuIC highly accurate.
• She co-authored the 2025 J Neurol report on the clinical picture of a novel PRNP A118V variant (Bari and ISS authors, study level) and the August 2026 J Neurol registry cohort of 599 sporadic CJD cases on sex differences in disease course.
• She is last author of the September 2026 Parkinsonism and Related Disorders study of 181 registry patients with rapidly progressive dementia and parkinsonism, where prion disease and Lewy body disease were the leading causes; Capellari, Parchi and Baiardi of Bologna are co-authors.
• From 2020 to 2025 she co-authored ISS COVID-19 mortality surveillance papers and was second author of the 2023 Italian good practice recommendations on Long-COVID care, with an ISS Department of Neuroscience affiliation.

Timeline

1. 2005to 2006 Visiting fellow in movement disorders, Sapienza University of Rome.
2. 2008First author JNNP camptocormia study, Sapienza affiliation.
3. 2010Neurology specialisation, Bucharest; from 2010 at the Sapienza movement disorders clinic (self reported).
4. 2013Co-author of the PLoS One E200K cluster age at death study with ISS authors.
5. 2017Co-author of the JAMA Neurology olfactory mucosa and CSF RT-QuIC study, ISS affiliation.
6. 2019First author of the R208H PRNP clinicopathological report, ISS Department of Neuroscience.
7. 2019Co-author of the Apulia sporadic CJD spatial epidemiology study.
8. 2022Co-author of the JAMA Network Open validation of revised sporadic CJD criteria, listed under the ISS CJD Registry.
9. 2022Co-author of the JNNP 10 year Italian CSF RT-QuIC study.
10. 2023Second author of Italian Long-COVID good practice recommendations.
11. 2024Listed as consultant neurologist on the ISS CJD registry staff list.
12. 2025Co-author of the A118V PRNP variant report.
13. 2026Co-author of the registry cohort study on sex differences in sporadic CJD.
14. 2026Last author of the registry study on rapidly progressive dementia with parkinsonism.