Simone Baiardi

Key facts

• Current title is Fixed-term Researcher in Tenure Track (L. 79/2022), Department of Biomedical and Neuromotor Sciences, University of Bologna, discipline MEDS-12/A Neurology.
• Research keywords on his university page are human prion disease and neurodegenerative disorders, with no active projects listed.
• Trained at the University of Bologna: MD 2010, Neurology specialization 2017, PhD 2019.
• Co-author of the 2017 Sci Rep study on second generation CSF RT-QuIC across CJD prion types, with Hughson and Caughey (RML) and Green (Edinburgh).
• Co-author of the 2020 skin punch biopsy RT-QuIC study (35 CJD patients, 89 percent sensitivity, 100 percent specificity) with Caughey.
• Co-author with Poleggi and Ladogana (ISS Rome) and Parchi of the 2022 review on RT-QuIC in CSF, olfactory mucosa and skin, including results by PRNP mutation.
• First author of a 2024 letter showing that an atypical genetic CJD (PRNP T183A-129M) did not transmit to transgenic mice.
• First author of the multicentric sCJD cortical subtype study of 56 patients with Appleby and Ladogana, online December 2025.
• Co-author of the 2024 plasma GFAP study in sporadic CJD, which found GFAP raised but weaker than 14-3-3 and tau.
• Co-author of the December 2024 study where the plasma BD-tau to p-tau217 ratio matched CSF 14-3-3 for separating CJD from other rapid dementias.
• Co-author of a 2025 CSF proteomics study defining sCJD subtypes, where one protein (CCDC80) predicted survival.
• Also works on alpha-synuclein seed amplification and NfL assays, including a 2025 Neurology perspective with Parchi and a first author NfL assay comparison.
• Co-author of a July 2026 Italian CJD Registry paper on rapidly progressive dementia with parkinsonism.

Timeline

1. 2010MD, University of Bologna.
2. 2017Neurology specialization; co-author of the second generation CSF RT-QuIC study.
3. 2019PhD, University of Bologna.
4. 2020Co-author of the skin punch biopsy RT-QuIC study.
5. 2022Co-author of the RT-QuIC diagnostic review with ISS Rome.
6. 2024Co-author of the plasma GFAP study in sporadic CJD.
7. 2024First author of the T183A genetic CJD transmission letter.
8. 2024Co-author of the CJD blood BD-tau study.
9. 2025First author of the sCJD cortical subtype study; co-author of the CSF proteomics study.
10. 2026Co-author of the Italian CJD Registry parkinsonism paper.