Sonia M. Vallabh

Codirector (with Eric Minikel) of the Broad Institute Prion Therapeutic Science program and co-founder of Prion Alliance, who co-leads PrP-lowering drug development from antisense to siRNA, epigenetic editing and base editing.

Key facts

  • Codirector of Broad's Prion Therapeutic Science program with Eric Minikel; senior group leader at the Broad.
  • Co-leads the program behind the first two PrP-lowering clinical trials the Broad team helped enable (ION717 and PRiSM) and the preclinical editing programs (CHARM, base editing, zinc finger repressors).
  • Collaborated with Ionis from 2014 and with the Khvorova lab from 2019 or 2020.
  • Funding: NIH grants and donations from the prion community to the Broad and Prion Alliance.
  • Co-founded Prion Alliance, which funds studies including OBSERVE and supports participant travel to trial sites.

Timeline

  1. 2019Collaboration with Khvorova begins (per Broad).
  2. 2024CHARM published in Science.
  3. 2025Base editing paper announced.
  4. 2026PRiSM launch announced.
  5. 2026PRiSM pre-symptomatic arm announced.

Institutions

Projects and trials

Research papers

Works with

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Last checked 15 October 2026

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